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Interstate 22 (I-22) is a 202.5-mile-long (325.9 km) Interstate Highway in the U.S. states of Mississippi and Alabama, connecting I-269 near Byhalia, Mississippi to I-65 near Birmingham, Alabama. I-22 is also Corridor X of the Appalachian Development Highway System. Designated in 2012, I-22 follows the route of the older U.S. Route 78. The freeway mainly spans rural areas and passes numerous small towns along its route, including Jasper, Winfield, and Hamilton, Alabama; and Fulton, Tupelo, New Albany, and Holly Springs, Mississippi.
I-22 was upgraded to Interstate Highway standards to close a gap in the Interstate Highway System, allowing for more direct connections between cities in the southeast with cities in the central part of the country. I-22 indirectly connects I-240, I-40, I-55, and I-69 in the Memphis metropolitan area via US 78 and I-269 with I-65 and I-20/I-59 in Birmingham.

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