Interstate 81 (I-81) is a north–south (physically northeast–southwest) Interstate Highway in the eastern part of the United States. Its southern terminus is at I-40 in Dandridge, Tennessee; its northern terminus is on Wellesley Island at the Canadian border, where the Thousand Islands Bridge connects it to Highway 401, the main Ontario freeway connecting Detroit via Toronto to Montreal. The major metropolitan areas that I-81 connects to include Harrisburg and the Wyoming Valley in Pennsylvania and Syracuse in New York.
I-81 largely traces the paths created down the length of the Appalachian Mountains through the Great Appalachian Valley by migrating animals, American Indians, and early settlers. It also follows a major corridor for troop movements during the Civil War. These trails and roadways gradually evolved into U.S. Route 11 (US 11); I-81 parallels much of the older US 11. Being mostly rural, it is heavily used as a trucking corridor, and is often used as a bypass of busier Interstates to the east such as I-95.
The Interstate 81 Corridor Coalition, a six-state coalition, was organized to handle issues along I-81, such as truck traffic and air pollution; the commission meets annually. I-81 is part of the fastest route between the capital of the United States (Washington, D.C.) and the capital of Canada (Ottawa).

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