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50/50 is a 2011 American comedy-drama film directed by Jonathan Levine, written by Will Reiser, and starring Joseph Gordon-Levitt, Seth Rogen, Anna Kendrick, Bryce Dallas Howard, and Anjelica Huston. The film is loosely inspired by Reiser's own experience with cancer, with Rogen's character Kyle based on Rogen himself. It was filmed from February to March 2010. 50/50 was released on September 30, 2011, and grossed $41 million, and received critical acclaim, with particular praise for Gordon-Levitt's performance and Reiser's screenplay.

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